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Gallic acid monohydrate

Gallic acid monohydrate

CAS: 5995-86-8

Molecular Formula: C7H8O6

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Gallic acid monohydrate - Names and Identifiers

Name Gallic acid monohydrate
Synonyms Gallic Acid, Hydrate
GALLIC ACID, HYDRATE
GALLIC ACID-1-HYDRATE
Gallic Acid-1-Hydrate
GALLIC ACID MONOHYDRATE
Gallic acid monohydrate
3,4,5-Trihydroxybenzoate
Gallic Acid(Monohydrate)
3,4,5-Trihydroxybenzoic Acid Hydrate
Gallic Acid, Monohydrate, Crystal, Reagent, ACS
CAS 5995-86-8
EINECS 611-919-7
InChI InChI=1/C7H6O5.H2O/c8-4-1-3(7(11)12)2-5(9)6(4)10;/h1-2,8-10H,(H,11,12);1H2
InChIKey IUTKPPDDLYYMBE-UHFFFAOYSA-N

Gallic acid monohydrate - Physico-chemical Properties

Molecular FormulaC7H8O6
Molar Mass188.13
Density1.694
Melting Point252°C (dec.)(lit.)
Boling Point596.6°C at 760 mmHg
Flash Point250°C
Water Solubility15 g/l (20 ºC)
Solubility Soluble in hot water, alcohol glycerin and acetone, slightly soluble in ether, insoluble in benzene, chloroform and petroleum ether.
Vapor Presure4.43E-15mmHg at 25°C
Appearancegrayish white to beige powder
ColorWhite to cream
Merck14,4345
BRN2050274
Storage ConditionKeep in dark place,Sealed in dry,Room Temperature
StabilityLight Sensitive
SensitiveHygroscopic
MDLMFCD00149098
Physical and Chemical PropertiesWhite or yellowish needle-like crystals, or prismatic crystals. It has silk luster and slightly sour taste. Soluble in ethanol, acetone, ethylene glycol, slightly soluble in water, ether.
In vitro study Gallic acid is an antioxidant which can inhibit both COX-2. After 18 h treatment with Gallic acid, the number of viable neutrophils is dramatically decreased from 40.3% to 27.7%, highly comparable with 26.4% for untreated neutrophils. Gallic acid fails to attenuate isoproterenol-induced myocytolysis.
In vivo study The food intake (2.6±0.08 g/day, p=0.69) and the body weight (2.5±0.69 g, p=0.76) of the Gallic acid group do not differ significantly from those of the control group (food intake; 2.41±0.14 g/day and the body weight; 2.83±0.84 g/day). The blood glucose tolerance in the Gallic acid group is significantly improved after 2 weeks of treatment. The blood glucose tolerance of the Gallic acid group after a treatment period of 2 weeks is also significantly better than that of the control group at 90 and 120 min ( p<0.05). The serum triglyceride concentration in the Gallic acid group (0.67±0.03 mM, p<0.05) is significantly reduced relative to that of the control group (1.08±0.20 mM). The total cholesterol concentration is similar in the control (3.19±0.27 mM) and Gallic acid (3.01±0.18 mM) groups.

Gallic acid monohydrate - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S24/25 - Avoid contact with skin and eyes.
WGK Germany2
RTECSLW7525000
FLUKA BRAND F CODES8-9-23
TSCAYes
HS Code29182900

Gallic acid monohydrate - Reference

Reference
Show more
1. [IF=4.952] Jiayue Gao et al."Reduction of oil uptake in deep-fried apple slices by the combined ultrasonic and ethanol pre-treatment."Lwt Food Sci Technol. 2021 Dec;152:112274
2. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155

Gallic acid monohydrate - Nature

Open Data Verified Data

in the form of tannins in Galla Chinensis, mistletoe bark and tea. White or yellowish needle-like crystals, or prismatic crystals. It has silk luster, slightly sour taste and astringency. Water of crystallization was lost at 100 N120 °c. Soluble in ethanol, acetone, ethylene glycol, water-soluble, ether. The relative density was 1. 694. Melting point 251 °c (decomposition).

Last Update：2024-01-02 23:10:35

Gallic acid monohydrate - Preparation Method

Open Data Verified Data

The Gallic Tannin was hydrolyzed under pressure to give gallic acid, which was further hydrolyzed to gallic acid and glucose. Reaction temperature 133~135 ℃, pressure 0. 1765~0.19 61MPA.

Last Update：2022-01-01 10:43:11

Gallic acid monohydrate - Introduction

No smell, slightly sour, turning brown when exposed to light. Heat to 100-120 ℃ and lose crystal water. There is convergence. Soluble in hot water, alcohol glycerin and acetone, slightly soluble in ether, insoluble in benzene, chloroform and petroleum ether. 1g dissolved in 87ml of water, 3ml of boiling water, 6ml of ethanol, 100ml of ether, 10ml of glycerin and 5ml of acetone. Half lethal dose (rabbit, oral) 5g/kg. It's irritating.
Last Update：2022-10-16 17:26:53

Gallic acid monohydrate - Use

Open Data Verified Data

pyrogallic acid, drugs, inks, media dyes can be prepared. Detection of free inorganic acid, two hydroxy acetone and alkaloids. It can also be used as a developer and as a food preservative for preparation of propyl gallate. Anti-explosion agents can also be prepared and used as analytical chemical reagents.

Last Update：2022-01-01 10:43:11

Gallic acid monohydrate - Safety

Open Data Verified Data
  • This product is slightly irritating, although it can produce methemosin to warm-blooded animals, but the toxicity is mild, the human body takes 2~4g daily, and does not show any symptoms of poisoning. Rats were injected subcutaneously with LD 4000mg/kg and frog LD 2000mg/kg.
  • industrial grade products are packed in plastic bags, 50kg per bag. Reagent grade products are packed in plastic bags, each bag 500g, packed in wooden boxes, each box 40 bags, net weight 20kg. Storage and transportation should pay attention to moisture, mildew, oxidation deterioration. Reagent grade products should be sealed and protected from light.
Last Update：2022-01-01 10:43:12

Gallic acid monohydrate - Reference Information

Biological activity Gallic acid (3,4, 5-Trihydroxybenzene acid) hydrate is a natural polyhydroxyphenolic compound that inhibits cyclooxygenase-2 (COX-2) Free radical scavenging effect. Gallic acid hydrate has a variety of activities, such as antibacterial, antioxidant, antibacterial, anti-inflammatory and anti-tumor activities.
target COX-2 Human Endogenous Metabolite
in vitro study Gallic acid is an antioxidant which can inhibit both COX-2. after 18   h treatment with Gallic acid, the number of viable neutrophils is dramatically decreased from 40.3% to 27.7%, highly comparable with 26.4% for untreated neutrophils. Gallic acid fail to attenuate isoproterenol-induced myocytolysis.
in vivo study The food intake (2.6±0.08g/day, p = 0.69) and the body weight (2.5±0.69g, P = 0.76) of the Gallic acid group do not differ significantly from those of the control group (food intake; 2.41±0.14g/day and the body weight; 2.83±0.84g/day). The blood glucose tolerance in the Gallic acid group is significantly improved after 2 weeks of treatment. The blood glucose tolerance of the Gallic acid group after a treatment period of 2 weeks is also significantly better than that of the control group at 90 and 120 min ( p<0.05). The serum triglyceride concentration in the Gallic acid group (0.67±0.03 mM, P <0.05) is significantly reduced relative to that of the control group (1.08±0.20 mM). The total cholesterol concentration is similar in the control (3.19±0.27 mM) and Gallic acid (3.01±0.18 mM) groups.
chemical properties white or light yellow needle crystals, or prismatic crystals. It has silk luster and slightly sour taste. Soluble in ethanol, acetone, ethylene glycol, slightly soluble in water, ether.
use used in the manufacture of thiazide dyes, oxazine dyes, drugs, etc.
used as a depolarization agent in electrochemical analysis; used to reduce phosphomolybdic acid; used to verify antimony, barium, bismuth, calcium, cerium and copper, etc; used for the determination of phosphorus, nitrite, silver, thorium and titanium, etc.
test free mineral acid, dihydroxyacetone and alkaloids, etc., depolarization agent in electro-chemical analysis, reduction of phosphomolybdic acid, and verification of antimony, Barium, bismuth, calcium, cerium and copper, etc. Determination of phosphorus, nitrite, silver, thorium and titanium.
category toxic substances
toxicity classification poisoning
acute toxicity vein-mouse LD50: 320 mg/kg
flammability hazard characteristics flammable, spicy and irritating smoke
storage and transportation characteristics warehouse low temperature, ventilation, drying
extinguishing agent water, carbon dioxide, dry powder, sand
Last Update：2024-04-09 20:49:11
Gallic acid monohydrate
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Product Name: Gallic acid monohydrate Request for quotation
CAS: 5995-86-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Gallic acid monohydrate Visit Supplier Webpage Request for quotation
CAS: 5995-86-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
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Gallic acid monohydrate
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